General Information

  • ID:  hor001808
  • Uniprot ID:  B0M3A1
  • Protein name:  Extended FMRFamide-2
  • Gene name:  NA
  • Organism:  Striatophasma naukluftense (Gladiator) (Heel-walker)
  • Family:  FARP (FMRF amide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Striatophasma (genus), Austrophasmatidae (family), Mantophasmatodea (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  ADYLQLAR
  • Length:  8(1-8)
  • Propeptide:  ADYLQLAR
  • Signal peptide:  NA
  • Modification:  T8 Arginine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  FMRFamides and FMRFamide-like peptides are neuropeptides.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001808_AF2.pdbhor001808_ESM.pdb

Physical Information

Mass: 107413 Formula: C42H68N12O13
Absent amino acids: CEFGHIKMNPSTVW Common amino acids: AL
pI: 6.34 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 4
Hydrophobicity: -20 Boman Index: -1586
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 122.5
Instability Index: 3888.75 Extinction Coefficient cystines: 1490
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  22508719
  • Title:  Peptidomics-based phylogeny and biogeography of Mantophasmatodea (Hexapoda).